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However, this reduced IGFBP binding comes with a pharmacokinetic trade-off: while native IGF-1 circulates with a half-life of 12-15 hours due to IGFBP stabilization, IGF-1 LR3 has a significantly shorter half-life of approximately 20-30 hours

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Patients should not expect all symptoms to be relieved by a daily bowel movement, and measures to aid bowel habits should be used judiciously

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