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And PE is able to establish hydrogen bonds with a variety of amino acid residues, which in turn inhibits the localization of negative amino acids on the cytoplasmic side, and is an important determinant of the topology of transmembrane structural domains of membrane proteins (Shi et al., 2024)

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Antes de pensar en DSIP, descarto causas comunes: apnea del sueño, reflujo nocturno, deficiencia de hierro o magnesio, hipertiroidismo, alcohol nocturno, cafeína tardía y ansiedad clínica no tratada