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Melillo agrees: "We can't definitively say that 0.5% is the minimum effective amount or that 1% will produce better results." The percentage on the label, it turns out, is almost beside the point

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However, the direct use of HGF or any other protein neurotrophic factor as a therapeutic agent has two serious limitations: 1) large size and hydrophilic character, which preclude BBB permeability

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