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The research demonstrates that effective doses typically fall within specific ranges [2]: The cagrilintide starting dose in most clinical protocols begins at 0.3 mg weekly, with gradual escalation over 8-12 weeks to minimize gastrointestinal side effects [3]

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With permanent vessel obstruction, once the therapeutic effect begins, the beneficial action proceeds without further reappearance of the adverse effects of vessel obstruction (Duzel et al., 2017