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(Biochem Pharmacol, 2001) examined melanocortin peptides on NF-κB DNA binding and nitric oxide production in RAW 264.7 macrophage-like cells and reported evidence for dual mechanisms of action

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Disse mekanismene er hittil utelukkende observert i prekliniske modeller og krever ytterligere forskning for å bekrefte deres overførbarheten til humane systemer